What you use for the thread sealant will also make a difference on how easily the thing turns. PTFE tape is a really good lubricant, and while it might seal things, you can often tighten it more than necessary. Some people use a combination of the tape and pipe dope. A pipe thread is tapered, so it's not like tightening a nut on a straight thread. How far you have to tighten it depends on how the pipe was threaded, the quality of the job (mostly, how sharp the die was). If the threads are torn from a dull die, it may take a bit more tightening to wedge enough of the tape or pipe dope into the gaps to seal things. The good thing is that the pipe and fittings are generally strong enough so you can actually tighten it more than you think you should (but probably don't need to).
There's probably a union in the mix, so, you can just unscrew the coupling nut, and take the parts apart. It doesn't hurt to put a little pipe dope on the mating parts, but it should not be needed. If the fitting was overtightened, though, it might have created a slight ridge, and if it doesn't line up, it can leak...the pipe dope can help.