Almost any Toto can be installed at 11-1/4" from the wall.
You don't need a 10" in your situation.
The Drake only needs 10-7/8" and installs like any other toilet.
Your other questions:
Cast iron drains are fine.
Toilets that use a Unifit, like the Vespin, Carlyle, Soiree and others can use the 12" that comes with the toilet, or replace that with a 10" or 14"
Performance is the same either way.
Below is a toilet that does use the Unifit adapter.
The one pictured is the Toto Carlyle.
In the Seattle area, I'm bringing in some 10" Toto Drake toilets.
They only need 9-1/4" to install.
CST744EF.10 or CST744SF.10
Comfort height, elongated bowl with either the 1.28 gallon Watersense Eco Flush
or the 1.6 gallon G-Max flush.
https://terrylove.com/pdf/cst744ef.10.pdf
TOTO now has a 10" dual flush at the factory.
I'm bringing some here for the
Seattle area.
CST412MF.10
Toto Vespin II CST474CEFG with SS114 Softclose seat.
This bowl was installed on a 13-1/2" rough-in using the 14" Unifit adapter.
The water shutoff can be as close as 5-1/2" to the left of center, unless it's higher off the floor, and then it can be even closer to center.
This shutoff had been replaced with a new 1/4 turn valve with brass nipple through the wall.
Installation was by James Love of Love Plumbing & Remodel 206-949-5683
In some of the older Seattle homes, the old toilets had been wall mounted tank toilets.
Those typically are 14" rough-in and need a flange repair to use standard closet bolt connections at the flange.
Everything is on the truck for that.
The Vespin comes with a standard 12" adapter or you can order a 10" or 14" adapter depending on your rough-in distance.