but do I manipulate the hub of the weir and have the street end of the weir straight into the outlet side of the trap u-bend; or manipulate the hub of the outlet of the trap u-bend (meaning the hub end of the weir is fully seated onto the drain like pipe end) ?
The weir is a point on the inside of the trap elbow, where if you slowly filled up the trap from the inlet side, water would first crest over and start spilling down the horizontal drain pipe going into the soil. So I think you mean trap elbow instead of weir.
All joints should be fully seated (well, if you end up with an internal gap of 1/8" or less, not worth redoing the joint)--you can't actually do that via a dry fit, as the plastic is an interference fit and depends on the solvent cement to soften both materials to fully seat the pipe/spigot end into the hub. While soft you can tweak that joint a tiny amount.
So if the trap outlet elbow is exactly 90 degrees (I've never checked it, could it be 91 degrees to help with the slope?), and if the u-bend has its two hub ends in exactly parallel planes, and if the joints were all perfectly coaxial, you are right that any slope on the trap arm would show up as an out-of-level condition on the u-bend inlet hub. But those are not all exactly true, and so you can get the u-bend inlet hub more level than that idealization would suggest. Even if the u-bend inlet hub is sloped 1% some way, you can fix that with your double 45 offset and the final result will work fine.
So dry fit the two pieces of the trap the best you can (deep enough so that everything is close to coaxial, but not so deep that you can't pull it apart again) and mark the orientations. Note how it is out of level on the u-bend inlet hub (if it all) and push/pull on the assembly in the proper place location to improve that. Glue it up, put your level on the u-bend inlet hub again, and if it is out of level the same way, push/pull on the assembly a bit as the glue hardens to improve the final result.
For the case of a planar p-trap, what you'd expect from the idealized model is that the far edge of the u-bend inlet hub would be a bit higher than the the downstream edge, and so pushing down on that far edge a bit would help reduce that discrepancy. While if you found any out-level-ness side to side, you'd rotate the trap elbow on the trap arm pipe to fix that. The geometry will be a bit different as your trap is not planar, but I'd guess something similar to be true--if in your picture the pipe is exiting the hole at 1 o'clock, you may need to push down a little on the trap inlet hub at around the 7 o'clock position. And/or push down a little on the trap elbow.
Cheers, Wayne