PEX will be damaged by UV, but if you can shield it, it can last. A nice feature is that it can expand, and the tubing itself typically does not get damaged if the water in it freezes. That does not mean the same is true for fittings, but since PEX is available in suck large rolls, often you can get by with only a fitting at the beginning and another at the end of the run, since you can just bend it to route it around a corner, I have radiant heat, and there's a lot of PEX in my place (at least by my standards). It's not all that big, and there's probably close to 850' of the stuff, only less than 20' or so is for potable water, though.
Any pipe, PEX, copper, included, can have mice or other animals chew through it, sometimes, just because it is there. With both PEX and CPVC (more so on PEX) the ID of a standard copper tubing size will be smaller (the lower strength requires the wall thickness increase). So, with PEX, to maintain the same frictional losses and ultimate volume, you may need to jump up to the next size over copper.