The reason I'm considering dual tank is the increased salt efficiency (doesn't need the 30% buffer/reserve) and to never run out of hard water, either during regeneration or if use increases significantly during the day. We often have visitors so water use can vary significantly day to day.
Our well pump is variable and can go up to 15gpm. My estimate: (220 ppm hardness / 17.1) * (6 people * 75 gals/day) * 7 days = ~40k grain at 6lb/cubic foot salt concentration. We don't have any iron and manganese is negligible (0.007 mg/L). Add an extra 30% for a single tank system and you're up to ~52k grain. I haven't looked at specific models and their specs yet, but using this (
http://media.wattswater.com/F-WQ-EngineeringGuide.pdf, page 12) as a general guide I would need about 2.5 cubic ft of resin, which is a 13" tank which backflows about 9gpm. That is 60% of the flow rate for backwashing and leaves 6gpm before the pressure starts dropping. Fill a bathtub, water the plants, etc. and I think you're pushing the 6gpm. For even more efficiency you can drop to 4lb/cubic foot of salt and/or regenerate every 2 weeks instead of 1. Dropping to 4lb seems doable, but 2 weeks would double the size of the tank and backwash flow rate.
Dual tank wouldn't need the 30% reserve capacity so I could probably drop to 2.0 cubic ft of resin which would decrease the backwash flow rate. That's 7gpm from the chart which leaves 8gpm for the house, most likely during the day.
Now, you did say 2.5gpm for a 10" tank, which is half what the chart I linked to shows. Maybe I should be looking at specs of specific models, but if it's half it would be 4.5gpm or 30% of the flow rate, leaving 11.5. That's quite a bit better than the 6gpm I came up with. Maybe I misunderstood the chart? The bottom of the flow rate column says it's the backwash rate and I assumed it was gpm.
I'm also not a pro, so if any of the above doesn't make sense please feel free to correct me. Thanks!