The truth is, you never give up. You just won't know if that next drug will work. Two years ago, I was told by my onc the drugs weren't working. Of course I already knew that. I tried, Rituxan again. Then, again. Sure, I grew a third eye, and another appendage, lol. but, it finally worked. So, you never know. I spent out of 10 years, 4 on chemo. But, I stop and think once in awhile~~just imagine, if I threw in the chips. Death is not an option, especially, with all the meds there are today. Even though I have NHL indolent and intermidate, I coordinate the breast cancer programs for the ACS. The success is a truly wonderful thing to see. No one needs to ever give up and abandon ship. Ever. We are learning so much.