Static pressure (no flow), will be the same everywhere except potential height differences and gravity effects. Dynamic pressure DOES vary depending on the diameter, length, number of fittings, and flow rate. There are a few things in a typical home that are not flow restricted: tub, outside hose bibs are the two most common. Most everything else is flow restricted. Then, you need to consider on a typical day, how many things will be drawing water at the same time. You have to decide whether you want a worst case situation, or can live with potential reduction in pressure and maybe volume if numerous things are opened up at the same time. Something like a shower with a lot of body sprays and shower heads would be overwhelmed by a 3/4" pex line and probably a 3/4" copper one as well...so, you need to evaluate your needs and desires.
A hot water recirculation system will negate any delay in the arrival of hot water and can save in both energy and resources. On a long run, that can cool off in between uses, you might be wasting 2-3 gallons or more each time you want hot water. That adds to your utility bill, decreases the useable volume in your water heater, and can be an issue in areas where water is more precious. Make sure to insulate the lines. It may make sense to put it on a timer if your typical day allows it.