Manablock offers not only crimp connections, but also compression ones which would be directly compatible with any PEX-A such as Uphonor's tubing.
One thing I just saw on Uphonor's website is something that is now required in Germany, and may be a consideration for use in the USA, too. This is a method to ensure there is no stagnant water in any of the lines in your house. Apparently required now on new construction in Germany.
It ensures that seldom used lengths of supply lines are constantly purged so that the water there can't become stagnant.
I didn't read the details, and there's probably a way around it, but caught one comment on the Manabloc's tech page is that their manifolds are not compatible with recirculation. That could be an issue, but you'd have to read the details as it's probably possible, but may be a bit more complicated.
Hot water recirculation can be quite useful depending on the system design, and in some places may be required as it (should) save water use. Instead of dumping potentially a few gallons each time you want hot water, it should be there immediately if recirculation is done right. If you insulate the lines, there isn't much of any energy cost, especially if you have it on either an on-demand operation, or a timer, and you've insulated all of the lines properly.