IF you like the looks of a wide spread but have a 4" c/c sink, you don't have a choice. The sink determines which one you use and they are not interchangeable.
Which one do you (or maybe your wife) prefer? Match that with a sink that fits it, and you're set...there is NO functional difference, it is only style. Personally, I prefer a single handle vanity faucet, but that's another issue altogether. you can buy single holed sinks, or offset it and put a soap dispenser in one of the other holes.