I'm remodeling my house and totally changed the layout... thus all the water, hydronic and DWV pipes had to go. It wasn't worth trying modify the existing system (house built in 50s). The whole system was copper, even had 3" vent stacks. I cut it all out and scrapped the copper, got about $1000 for it. Granted there is still a little bit of copper left (near water meter and around boiler).
I decided to redo the system in PEX. The advantage to PEX is when you install it "home-run" style, ideally you only need 2 connections. PEX is pretty flexible and thus reduces the number of connections needed. I crimped my connections (copper rings). I spent more time planning the system, then actually installing it.
I plan on installing baseboard or panel heaters throughout the house and will use 3/4" oxygen barrier PEX for each loop/room.
You *can* replicate the copper layout, however remember that PEX has a smaller ID than copper of the same "size". As such, the same system in PEX (identical layout and pipe size) will have higher flow losses, which will either need a larger circulator (to overcome those losses) or have reduced heat output (BTU/hr).