If you're asking abaout threaded nuts on a PVC drain assembly, actually those are made to hand-tighten, but sometimes people will give them an extra quarter-turn with a wrench or channel-locks, or mistakenly "glue" them with PVC glue.
They are pretty brittle, and can crack easily if too much pressure from a wrench is applied in either direction.
You can easily replace the nuts and plastic washers (they come separately) and re-assemble the threaded fittings. Turn the washers so that the flat side is toward the nut, and the beveled end is toward the pipe. You don't need glue on them.
Good luck!
Mike